Study of Binaural Auditory Cortical Response in Children with History of Recurrent Otitis.

Introduction Any type of sensory deprivation in childhood resulting from conductive hearing loss may impair the development of peripheral and central auditory pathway structures with negative consequences for binaural processing. Objective To characterize and compare monoaural and binaural auditory responses in neonates and children without and with a history of recurrent otitis. Methods The study included participants from 0 to 8 years and 11 months old, in good general health conditions, of both genders, divided into a control group, with no history of otitis, and a study group, with history of recurrent otitis. Cortical potential with speech stimulus /ba/-/da/ was used as collection procedure. The arithmetic calculation of the 512 points of the wave was performed to obtain the grand average of the waves of the subjects in both groups. The Shapiro-Wilk and mixed repeated measures analysis of covariance (ANCOVA) statistical tests were performed to analyze the group effect, the condition, and the interaction (group versus condition) controlling the effect of the age-sex covariable. Results There was a statistically significant difference between the groups for all latency values; and for the P1, N1, P2, and N2 latencies, the differences between the groups occurred in the three analyzed conditions (right and left ears and binaural), revealing the influence of sensory deprivation. There were no significant differences in relation to wave amplitudes. Conclusion There are differences in the cortical potential with speech stimuli and in the binaural interaction component of children with and without history of recurrent otitis.

Analysis of the Effect of Musical Stimulation on Cortical Auditory Evoked Potentials

Abstract Introduction Cortical auditory evoked potentials (CAEPs) are bioelectric responses that occur from acoustic stimulations, and they assess the functionality of the central auditory system. Objective The objective of the present study was to analyze the effect of musical stimulation on CAEPs. Methods The sample consisted of 42 healthy female subjects, aged between 18 and 24 years, divided into two groups - G1: without musical stimulation prior to the CAEP examination; and G2: with stimulation prior to the examination. In both groups, as a pre-collection procedure, the complete basic audiological evaluation was performed. For the musical stimulation performed in G2, we used an MP4 player programmed to play Pachelbel's "Canon in D Major" for five minutes prior to the CAEP examination. To analyze the effect on the groups, the ear side and the ide-group interaction , a mixed analysis of variance (ANOVA) of repeated measures was performed. Box M test and Mauchly sphericity test were also performed. Results Test differences were considered statistically significant when the p-value was < 0.05 (5%). Thus, it was possible to observe that there was a statistically significant difference of the P2 component characterized by the decrease in the amplitude of response in the left ear in G2 when comparing the responses of CAEP with and without prior musical stimulation. Conclusion The result of the present study enabled us to conclude that there was a change in the response of CAEPs with musical stimulation. (AU)

Analysis of the Effect of Musical Stimulation on Cortical Auditory Evoked Potentials.

Introduction Cortical auditory evoked potentials (CAEPs) are bioelectric responses that occur from acoustic stimulations, and they assess the functionality of the central auditory system. Objective The objective of the present study was to analyze the effect of musical stimulation on CAEPs. Methods The sample consisted of 42 healthy female subjects, aged between 18 and 24 years, divided into two groups - G1: without musical stimulation prior to the CAEP examination; and G2: with stimulation prior to the examination. In both groups, as a pre-collection procedure, the complete basic audiological evaluation was performed. For the musical stimulation performed in G2, we used an MP4 player programmed to play Pachelbel's "Canon in D Major" for five minutes prior to the CAEP examination. To analyze the effect on the groups, the ear side and the ide-group interaction , a mixed analysis of variance (ANOVA) of repeated measures was performed. Box M test and Mauchly sphericity test were also performed. Results Test differences were considered statistically significant when the p -value was < 0.05 (5%). Thus, it was possible to observe that there was a statistically significant difference of the P2 component characterized by the decrease in the amplitude of response in the left ear in G2 when comparing the responses of CAEP with and without prior musical stimulation. Conclusion The result of the present study enabled us to conclude that there was a change in the response of CAEPs with musical stimulation.

P300: Waves Identification with and without Subtraction of Traces.

Introduction The P300 test requires well-defined and unique criteria, in addition to training for the examiners, for a uniform analysis of studies and to avoid variations and errors in the interpretation of measurement results. Objectives The objective of this study is to verify whether there are differences in P300 with and without subtraction of traces of standard and nonstandard stimuli. Method We conducted this study in collaboration with two research electrophysiology laboratories. From Laboratory 1, we selected 40 tests of subjects between 7-44 years, from Laboratory 2, we selected 83 tests of subjects between 18-44 years. We first performed the identification with the nonstandard stimuli; then, we subtracted the nonstandard stimuli from the standard stimuli. The examiners identified the waves, performing a descriptive and comparative analysis of traces with and without subtraction. Results After a comparative analysis of the traces with and without subtraction, there was no significant difference when compared with analysis of traces in both laboratories, within the conditions, of right ears ( p = 0.13 and 0.28 for differences between latency and amplitude measurements) and left ears ( p = 0.15 and 0.09 for differences between latency and amplitude measurements) from Laboratory 1. As for Laboratory 2, when investigating both ears, results did not identify significant differences ( p = 0.098 and 0.28 for differences between latency and amplitude measurements). Conclusion There was no difference verified in traces with and without subtraction. We suggest the identification of this potential performed through nonstandard stimuli.

P300: Waves Identification with and without Subtraction of Traces

Abstract Introduction The P300 test requires well-defined and unique criteria, in addition to training for the examiners, for a uniform analysis of studies and to avoid variations and errors in the interpretation of measurement results. Objectives The objective of this study is to verify whether there are differences in P300 with and without subtraction of traces of standard and nonstandard stimuli. Method We conducted this study in collaboration with two research electrophysiology laboratories. From Laboratory 1, we selected 40 tests of subjects between 7 44 years, from Laboratory 2, we selected 83 tests of subjects between 18 44 years. We first performed the identification with the nonstandard stimuli; then, we subtracted the nonstandard stimuli fromthe standard stimuli. The examiners identified the waves, performing a descriptive and comparative analysis of traces with and without subtraction. Results After a comparative analysis of the traces with and without subtraction, there was no significant difference when compared with analysis of traces in both laboratories, within the conditions, of right ears (p = 0.13 and 0.28 for differences between latency and amplitude measurements) and left ears (p = 0.15 and 0.09 for differences between latency and amplitude measurements) from Laboratory 1. As for Laboratory 2, when investigating both ears, results did not identify significant differences (p = 0.098 and 0.28 for differences between latency and amplitude measurements). Conclusion There was no difference verified in traces with and without subtraction. We suggest the identification of this potential performed through nonstandard stimuli.

Potenciais corticais auditivos: uso de diferentes estímulos de fala em populações infantis / Auditory cortical potential: using different types of speech stimuli in children

RESUMO Introdução Os potenciais evocados auditivos são respostas elétricas que ocorrem nas vias auditivas centrais, resultantes de estimulação acústica. O uso de estímulos de fala para eliciar a resposta desses potenciais possibilita a compreensão de informações sobre codificação e decodificação da fala no sistema nervoso central. Objetivo Comparar o resultado do potencial evocado auditivo de latência longa com dois diferentes estímulos de fala. Métodos Participaram do estudo 30 escolares saudáveis, de ambos os sexos, com idade entre 8 e 12 anos. Para os potenciais evocados auditivos, foram utilizados dois diferentes estímulos de fala para a discriminação auditiva: Teste 1 /ba/ x /da/ e Teste 2 /pa/ x /da/. Os estímulos foram aleatoriamente apresentados, sendo 20% raros e 80% frequentes. Os escolares participaram de uma tarefa auditiva ativa e disseram [da] para identificar os estímulos raros. A normalidade dos dados foi determinada utilizando o teste de Shapiro-Wilk. Para comparar a média com o Teste 1 e Teste 2, foi realizada a estimulação t de Student. Resultados Houve diferença significativa na latência P3 na orelha direita, amplitude P2 na orelha direita e amplitude P3 na orelha esquerda. Ocorreram valores mais longos com estímulo /ba/ x /da/. Conclusão As respostas dos potenciais evocados auditivos de latência longa variam em função do estímulo e do cuidado em sua análise, quando se utilizam estímulos de fala na avaliação.

ABSTRACT Introduction Auditory Evoked Potentials are electrical responses that occur in the central auditory pathways, resulting from acoustic stimulation. The use of speech stimuli to elicit the response of these potentials allows to understand information about speech coding and decoding in the central nervous system. Purpose To compare the Long Latency Auditory Evoked Potential of two different speech stimuli. Methods Thirty healthy school children of both genders, aged between 8 and 12 years, participated in the study. For the auditory evoked potentials, different speech stimuli were used for the auditory discrimination: Test 1 /ba/ x /da/ and Test 2 /pa/ x /da/. The stimuli were randomly presented: 20% infrequent and 80% frequent. The school children participated in an active auditory task and said [da] to identify the infrequent stimuli. The normality of the data was determined using the Shapiro-Wilk test. To compare the mean with Test 1 and Test 2, stimulation was performed using Student t test. Results There was a significant difference in P3 latency in the right ear, P2 amplitude in the right ear and P3 amplitude in the left ear. Longer values occurred with stimulus /ba/ x /da/. Conclusion The responses of long latency auditory evoked potentials vary depending on the stimulus and care in the analysis when using speech stimuli in the evaluation.

Uso do potencial evocado auditivo de média latência em populações infantis: uma revisão integrativa / Use of middle latency auditory evoked potentials in children: an integrative review

RESUMO Este estudo teve como objetivo investigar na literatura a utilidade do Potencial evocado auditivo de média latência na população infantil para o estudo do sistema auditivo em seus processos normais e desviantes. A revisão integrativa da literatura científica consistiu na busca de estudos utilizando as bases de dados: PubMed, Scopus e Scielo. Como descritores para a pesquisa foram utilizados os termos: "auditory middle latency response" "auditory middle latency potential" , "children", "child", "childhood", "maturation' e "development". Os estudos eram artigos completos, cujos participantes foram crianças, submetidas ao exame de Potencial evocado auditivo de média latência. A análise dos estudos individualmente verificou aspectos relacionados ao objetivo da pesquisa, a metodologia utilizada e a conclusão de cada estudo. Foram selecionados e lidos na íntegra um total de 11 estudos da base bibliográfica PubMed, oito estudos da Scopus e dois estudos da Scielo. Do total de 21 artigos, seis deles foram realizados com crianças saudáveis, quatro examinaram os componentes desse potencial em crianças com distúrbio de linguagem ou distúrbio específico de linguagem, quatro estudos avaliaram crianças usuárias de implante coclear, e sete crianças com outras alterações. Esta revisão integrativa mostrou a importância da investigação dos potenciais evocados auditivos de média latência em crianças. Tal avaliação vem permitindo um diagnóstico mais precoce e preciso de pacientes com alterações de linguagem, fala ou de aprendizado e de distúrbios do processamento auditivo além do monitoramento de evolução terapêutica.

ABSTRACT This study aimed to investigate, in the literature, the use of middle latency auditory evoked potentials in children to study the auditory system in its normal and deviant processes. The integrative scientific literature review consisted of searching studies using PubMed, Scopus and Scielo databases. The search terms descriptors were: "auditory middle latency response ", "auditory middle latency potential", "children", "child", "childhood", "maturation" and "development". The selected studies were full papers whose participants were children who underwent middle latency auditory evoked potentials exams. The analysis of the studies, individually, verified aspects related to the aim of the research, the methodology used and the conclusion of each study. A total of 11 studies retrieved from PubMed, eight from Scpus and two studies from Scielo were selected and read in full. Out of the 21 articles, six investigations had been carried out with healthy children, four of them examined the components of this potential in children with language disorders or specific language disorders, four studies assessed children with cochlear implants and seven investigations with children with other changes. This integrative review showed the importance of research of Middle Latency Auditory Evoked Potentials in children. Such an assessment has allowed earlier and accurate diagnosis of patients with language, speech or learning disorders as well as auditory processing disorders, in addition to monitoring therapeutic evolution.

Potencial evocado auditivo de média latência em populações infantis / Middle latency auditory evoked potential in child population

INTRODUCTION: The middle-latency auditory evoked potential is used to evaluate any abnormality that might impair the central auditory pathways, which are situated between the brain stem and the primary auditory cortex OBJECTIVE: To analyse the middle-latency auditory evoked potentials in children Methods : This is a descriptive and cross-sectional study. Pure-tone audiometry was performed, and if no change was detected, Biologic's portable Evoked Potential System (EP) was used to measure auditory evoked potentials. The identification of the responses was performed using electrodes positioned at C3 and C4 (left and right hemispheres) in reference to ears A1 and A2 (left and right earlobe). These were ipsilaterally and contralaterally paired and landed at Fpz (forehead), in two steps, with alternating stimulation of the right and left ears. RESULTS: In this study, there was 100% detectability of the Na, Pa, and Nb components and interamplitude Na-Pa. This study compared different electrode leads, and there was no significant difference between the different electrode positions studied for the right and left ears in the studied population CONCLUSION: It was concluded that the examination of middle-latency evoked potential is steady and feasible for the studied age group regardless of electrode position

INTRODUÇÃO: O potencial evocado auditivo de média latência é utilizado na avaliação de qualquer anomalia que possa comprometer as vias auditivas centrais, situadas entre o tronco encefálico e córtex auditivo primário OBJETIVO: Analisar os potenciais evocados auditivos de média latência em escolares MÉTODO: Esse estudo é descritivo transversal. Como procedimento foi realizado a audiometria tonal, e caso não fosse detectada nenhuma alteração, foi utilizado o equipamento portátil de potencial evocado auditivo Biologic's Evoked Potencial System (EP). O registro das respostas foi efetuado com eletrodos posicionados em C3 e C4 (hemisfério esquerdo e direito, respectivamente) em referência às orelhas A1 (lóbulo da orelha esquerda) e A2 (lóbulo da orelha direita), pareados ipsilateralmente e contralateralmente e terra em Fp (fronte), em duas etapas, alternando as estimulações das orelhas direita e esquerda RESULTADOS: Neste estudo houve 100% de detectabilidade dos componentes Na, Pa, Nb e interamplitude Na-Pa. Foram comparadas diferentes derivações de eletrodo e não foi observada diferença significativa entre diferentes posições de eletrodos pesquisadas tanto para orelha direita quanto para orelha esquerda nesta população de estudo CONCLUSÃO: O exame de potencial evocado auditivo de média latência é estável e viável para faixa etária estudada independente da posição dos eletrodos